Hulitherium was described on the basis of a nearly complete skull, several detached teeth, a fragment of lower jaw, atlas and cervical vertebrae, almost complete humerus and fragmentary bones of the hind limb. the skeleton suggests that the limbs were highly mobile relative to the other diprotodontids and that it was a browser.
Hulitherium lived in montane rain forests and may have fed on bamboo. perhaps a marsupial analogue of the giant panda. It was one of New Guinea's largest mammals with the height of 1 m (3 ft) and was close to 2 m (6 ft) long. And the estimated weight of 75-200 kilograms. Flannery and Plane (1986) suggested that because little had changed since the Late Pleistocene, humans may have been the major factor that led to its extinction.